Breakthrough Business Models: Drug Development for Rare and Neglected Diseases and Individualized Therapies: Workshop Summary

By Theresa M. Wizemann

"The Institute of Medicine's Forum on Drug Discovery, Development, and Translation held a public workshop on June 23, 2008, titled "Breakthrough Business Models: Drug Development for Rare and Negle...

Systems for research and evaluation for translating genome based discoveries for health

By Theresa M. Wizemann

The public health emergency medical countermeasures enterprise

By Theresa M. Wizemann, Bruce M. Altevogt, Clare Stroud

"During public health emergencies such as pandemic influenza outbreaks or terrorist attacks, effective vaccines, drugs, diagnostics, and other medical countermeasures are essential to protecting na...

Sex differences and implications for translational neuroscience researach

By Theresa M. Wizemann, Bruce M. Altevogt, Diana E. Pankevich

"Biological differences between the sexes influence not only individual health but also public health, biomedical research, and health care. The Institute of Medicine held a workshop March 8-9, 201...

Future opportunities to leverage the Alzheimer's Disease Neuroimaging Initiative

By Theresa M. Wizemann, Bruce M. Altevogt, Diana E. Pankevich

"Nearly 5.3 million Americans are living with Alzheimer's disease, and 26.6 million people are affected worldwide. The Alzheimer's Disease Neuroimaging Initiative (ADNI), a public-private partnersh...

Public health effectiveness of FDA 510 k clearance process

By Theresa M. Wizemann

"The Food and Drug Administration (FDA) is responsible for ensuring that medical devices are safe and effective before they go on the market. Section 510(k) of the Federal Food, Drug, and Cosmetic...

Health literacy implications for health care reform

By Theresa M. Wizemann

Health literacy is the degree to which one can understand and make decisions based on health information. Nearly 90 million adults in the United States have limited health literacy. While poor heal...

Preparedness and response to a rural mass casualty incident

By Theresa M. Wizemann, Bruce M. Altevogt, Kristin Viswanathan

Problems contacting emergency services and delayed assistance are not unusual when incidents occur in rural areas, and the consequences can be devastating, particularly with mass casualty incidents...

Generating evidence for genomic diagnostic test development

By Theresa M. Wizemann, Adam C. Berger

"Ten years after the sequencing of the human genome, scientists have developed genetic tests that can predict a person's response to certain drugs, estimate the risk of developing Alzheimer's disea...

Advancing regulatory science for medical countermeasure development

By Theresa M. Wizemann

Whether or not the United States has safe and effective medical countermeasures--such as vaccines, drugs, and diagnostic tools--available for use during a disaster can mean the difference between l...